Effective Date: December 02, 2011
Expiration Date: December 02, 2020
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Vertebrate Animal Scientific Review (VASR)
If vertebrate animals are to be used, the following five points must be addressed completely by applicants in the VASR worksheet of their proposal:
1. Detailed description of the proposed use of the animals, including species, strains, ages, sex and number to be used.
2. Justification of the use of animals, choice of species and numbers to be used, and proposer's assessment of potential benefits and knowledge to be gained.
3. Information on the veterinary care of the animals.
4. Description of procedures for ensuring discomfort, distress, pain, and injury are minimized.
5. Method of euthanasia and the reasons for its selection.
Each of the five points must be addressed, for all performance sites, in the VASR worksheet. The VASR worksheet will be reviewed by the scientific merit review panel and the proposal coded as either No Vertebrate Animals, No Concerns/Acceptable, or Concerns/Unacceptable. If coded as Unacceptable, NASA staff will work with the applicant to resolve concerns prior to award. Coding of the proposal as Acceptable or No Vertebrate Animals is required prior to award.
In order to be coded as "No vertebrate animals" the vertebrate tissue used in the study will be obtained from other sources (e.g., tissue repository, animals euthanized for an unrelated purpose). The source of the tissue should be included in the VASR to validate the coding as no vertebrate animals used. If vertebrate tissues are obtained through euthanasia for tissue harvest, the proposed research is coded as use of live vertebrate animals. The generation of custom antibodies is coded as use of live vertebrate animals.
A "performance site(s)" is defined as the institutions where procedures with animals will be performed. If the applicant institution is not the site where animal work will be performed, the performance site must be identified. If there is more than one performance site, the description of animal care and use at each site must be included and must address the five points.
Applicants should be aware that NASA may release information contained in funded proposals pursuant to a Freedom of Information Act request.
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