| AA | Assistant Administrator |
| ANACI | Access National Agency Check and Inquiries |
| ARC | Automated Records Check |
| BI | Background Investigation |
| CAF | Central Adjudication Facility |
| CARP | Credentialing Adjudication Review Panel |
| CCS | Center Chief of Security |
| CEA | Center Export Administrator |
| CEP | Continuous Evaluation Program |
| CNACI | Child Care National Agency Check and Inquiries |
| CNSI | Classified National Security Information |
| COTR | Contracting Officer's Technical Representative |
| CCPS | Center Chief of Protective Services |
| CCS | Center Chief of Security |
| CNWDI | Critical Nuclear Weapons Design Information |
| CS | Critical Sensitive |
| CVS | Central Verification System |
| DAA | Designated Approving Authority |
| DISCO | Defense Industrial Security Clearance Office |
| DOE | Department of Energy |
| EO | Executive Order |
| EOD | Entry on Duty Date |
| E-QIP | Electronic Questionnaires for Investigation Processing |
| FISD | Federal Investigative Services Division (OPM) |
| FRD | Formerly Restricted Data |
| IPA | Intergovernmental Personnel Act |
| HSPD | Homeland Security Presidential Directive |
| ITAR | International Traffic in Arms Regulation |
| ITS | Information Technology System |
| IVC | International Visitor Coordinator |
| LAA | Limited Access Authorization |
| LOI | Letter of Intent |
| LON | Letter of Notice |
| LPR | Lawful Permanent Resident |
| MBI | Moderate Risk Background Investigation |
| MEI | Mission Essential Infrastructure (replaced by NCI-NASA Critical Infrastructure) |
| MOA | Memorandum of Agreement |
| MOU | Memorandum of Understanding |
| NAC | National Agency Check |
| NACI | National Agency Check and Inquiries |
| NACLC | National Agency Check with Law and Credit |
| NCI | NASA Critical Infrastructure (formerly, MEI- Mission Essential Infrastructure) |
| NCIC | National Crime Information Center (DOJ) |
| NCTS | NASA Clearance Tracking System |
| NPD | NASA Policy Directive |
| NRC | Nuclear Regulatory Commission |
| NPR | NASA Procedural Requirement |
| NSD | National Security Directive |
| OCA | Original Classification Authority |
| OGC | Office of General Counsel |
| OCHCO | Office of the Chief Human Capital Officer |
| OIIR | Office of International and Interagency Relations |
| OPF | Official Personnel File |
| OPM | Office of Personnel Management |
| OPMIS | Office of Personnel Management's Investigative Service |
| OPS | Office of Protective Services |
| PII | Personally Identifiable Information |
| PIPS | Personnel Investigations Processing System |
| PIV | Personal Identity Verification |
| PPO | Program Protection Office |
| PRA | Permanent Resident Alien |
| PRI | Periodic Reinvestigation |
| PSI | Personnel Security Investigation (formerly Background Investigation) |
| RD | Restricted Data |
| ROI | Report of Investigation |
| SAP | Special Access Program |
| SARP | Security Adjudication Review Panel |
| SCI | Sensitive Compartmented Information |
| SF | Standard Form |
| SII | Security/Suitability Investigations Index |
| SMD | Director, Security Management Division |
| SSBI | Single Scope Background Investigation |
| TDP | Testing Designated Position |
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