| AA | Associate Administrator |
| AA/OCOM | Assistant Administrator, Office of Communications |
| AA/OIIR | Assistant Administrator, Office of International and Interagency Relations |
| AMD | Aircraft Management Division |
| AO | Appointing Official |
| AOA | Angle of Attack |
| CAP | Corrective Action Plan |
| CD | Center Director |
| Chief/OSMA | Chief, Office of Safety and Mission Assurance |
| EAR | Export Administration Regulations |
| ED/OHO | Executive Director, Office of Headquarters Operations |
| FAA | Federal Aviation Administration |
| FAR | Federal Acquisition Regulation |
| FEMA | Federal Emergency Management Agency |
| FISMA | Federal Information Security Management Act |
| FOIA | Freedom of Information Act |
| HQ | NASA Headquarters |
| HIPAA | Health Insurance Portability and Accounting Act |
| IA | Investigating Authority |
| IRT | Interim Response Team |
| ITAR | International Traffic in Arms Regulations |
| LLIS | Lessons Learned Information System |
| LSP | Launch Services Program |
| MDAA | Mission Directorate Associate Administrator |
| MI | Mishap Investigator |
| MIB | Mishap Investigation Board |
| MISO | NSC Mishap Investigation Support Office |
| MIT | Mishap Investigation Team |
| MPCP | Mishap Preparedness and Contingency Plan |
| MWAR | Mishap Warning-Action-Response |
| NASA | National Aeronautics and Space Administration |
| NDA | Nondisclosure Agreement |
| NFS | NASA FAR Supplement |
| NMIS | NASA Mishap Information System |
| NPD | NASA Policy Directive |
| NPR | NASA Procedural Requirements |
| NRRS | NASA Record Retention Schedules |
| NSC | NASA Safety Center |
| NTSB | National Transportation Safety Board |
| OCE | Office of the Chief Engineer |
| OCF | Out of Controlled Flight |
| OCHMO | Office of the Chief Health and Medical Officer |
| OCOM | Headquarters Office of Communications |
| OIG | Office of Inspector General |
| OIIR | Office of International and Interagency Relations |
| OPS | Office of Protective Services |
| OSHA | Occupational Safety and Health Administration |
| OSI/AMD | Office of Strategic Infrastructure, Aircraft Management Division |
| OSMA | Office of Safety and Mission Assurance |
| PAO | Center Public Affairs Office |
| SATERN | System for Administration, Training, and Educational Resources for NASA |
| SBU | Sensitive But Unclassified |
| SMA | Safety and Mission Assurance |
| WBT | Web-Based Training |
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