| AA | Associate Administrator |
| ABC | Agency Baseline Commitment |
| ACD | Architectural Control Document |
| AI&T | Assembly, Integration, and Test |
| AO | Announcement of Opportunity |
| APMC | Agency Program Management Council |
| ASM | Acquisition Strategy Meeting |
| BOE | Basis of Estimate |
| BPR | Baseline Performance Review |
| CADRe | Cost Analysis Data Requirement |
| CD | Center Director |
| CDR | Critical Design Review |
| CE | Chief Engineer |
| CERR | Critical Events Readiness Review |
| CFO | Chief Financial Officer |
| CHMO | Chief Health and Medical Officer |
| CMC | Center Management Council |
| COI | Conflict of Interest |
| COOP | Continuity of Operations |
| CPD | Center Policy Directive |
| CPR | Center Procedural Requirements |
| CRM | Continuous Risk Management |
| CSO | Chief Safety and Mission Assurance Officer |
| DA | Decision Authority (also Deputy Administrator) |
| DOD | Department of Defense |
| DR | Decommissioning Review |
| DRD | Data Requirements Description |
| DRM | Design Reference Mission |
| DRR | Disposal Readiness Review |
| EAC | Estimate at Completion |
| EC | Executive Council |
| ECC | Education Coordinating Council |
| ELV | Expendable Launch Vehicle |
| EMD | Environmental Management Division |
| EMS | Environmental Management System |
| EOMP | End of Mission Plan |
| ETA | Engineering Technical Authority |
| EVM | Earned Value Management |
| FAD | Formulation Authorization Document |
| FAR | Federal Acquisition Regulation |
| FC | Fully Compliant |
| FRED | Facilities Real Estate Division |
| FRR | Flight Readiness Review |
| FTE | Full-Time Employee |
| GDS | Ground Data System |
| GFY | Government Fiscal Year |
| HMTA | Health and Medical Technical Authority |
| ICD | Interface Control Document |
| ICMC | Integrated Center Management Council |
| ILS | Integrated Logistics Support |
| IMS | Integrated Master Schedule |
| IPMR | Integrated Program Management Report |
| IT | Information Technology |
| JCL | Joint Cost and Schedule Confidence Level |
| JPL | Jet Propulsion Laboratory, a Federally Funded Research and Development Center |
| KDP | Key Decision Point |
| LCC | Life-Cycle Cost |
| LCR | Life-Cycle Review |
| LDE | Lead Discipline Engineer |
| LMD | Logistics Management Division |
| LRR | Launch Readiness Review |
| MCR | Mission Concept Review |
| MD | Mission Directorate |
| MDAA | Mission Directorate Associate Administrator |
| MdM | Meta-Data Manager |
| MDPMC | Mission Directorate Program Management Council |
| MDR | Mission Definition Review |
| MOA | Memorandum of Agreement |
| MOS | Mission Operations System |
| MOU | Memorandum of Understanding |
| MRB | Mission Readiness Briefing |
| MRR | Mission Readiness Review |
| MSD | Mission Support Directorate |
| MSO | Mission Support Office |
| MSOD | Mission Support Office Director |
| NA | Not Applicable |
| NEN | NASA Engineering Network |
| NEPA | National Environmental Policy Act |
| NESC | NASA Engineering and Safety Center |
| NFS | NASA Federal Acquisition Regulation (FAR) Supplement |
| NID | NASA Interim Directive |
| NOA | New Obligation Authority |
| NODIS | NASA On-Line Directives Information System |
| NPD | NASA Policy Directive |
| NPR | NASA Procedural Requirements |
| OCE | Office of the Chief Engineer |
| OCFO | Office of the Chief Financial Officer |
| OCHMO | Office of the Chief Health and Medical Officer |
| OCIO | Office of the Chief Information Officer |
| OCT | Office of the Chief Technologist |
| OComm | Office of Communications |
| ODAR | Orbital Debris Assessment Report |
| OER | Office of External Relations |
| OGC | Office of General Counsel |
| OIIR | Office of International and Interagency Relations |
| OMB | Office of Management and Budget (Executive Office of the White House) |
| OPS | Office of Protective Services |
| ORR | Operational Readiness Review |
| OSMA | Office of Safety and Mission Assurance |
| PCA | Program Commitment Agreement |
| PCE | Program (or Project) Chief Engineer |
| PDLM | Product Data and Life-Cycle Management |
| PDR | Preliminary Design Review |
| PFAR | Post-Flight Assessment Review |
| PI | Principal Investigator |
| PIR | Program Implementation Review |
| PLAR | Post-Launch Assessment Review |
| PMB | Performance Measurement Baseline |
| PMC | Program Management Council |
| PPBE | Planning, Programming, Budgeting, and Execution |
| PRA | Probabilistic Risk Assessment |
| PRR | Production Readiness Review |
| PSM | Procurement Strategy Meeting |
| RFA | Request for Action |
| RFP | Request for Proposal |
| RID | Review Item Discrepancy |
| RIDM | Risk-Informed Decision Making |
| SAR | System Acceptance Review |
| SDR | System Definition Review |
| SEMP | Systems Engineering Management Plan |
| SI | Système Internationale (or metric) system of measurement |
| SID | Strategic Investments Division |
| SIR | System Integration Review |
| SMA | Safety and Mission Assurance |
| SMATA | Safety and Mission Assurance Technical Authority |
| SMC | Strategic Management Council |
| SMD | Science Mission Directorate |
| SMSR | Safety and Mission Success Review |
| SRB | Standing Review Board |
| SRR | System Requirements Review |
| STEM | Science, Technology, Engineering, and Mathematics |
| TA | Technical Authority |
| TBD | To Be Determined |
| TBR | To Be Resolved |
| TRL | Technology Readiness Level |
| ToR | Terms of Reference |
| UFE | Unallocated Future Expenses |
| V&V | Verification and Validation |
| WBS | Work Breakdown Structure |
| WYE | Work Year Equivalent |
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