| AO | Announcement of Opportunity |
| ASM | Acquisition Strategy Meeting |
| CD | Center Director |
| CDR | Critical Design Review |
| CERR | Critical Events Readiness Review |
| CIO | Chief Information Officer |
| CM | Configuration Management |
| CMM | Capability Maturity Model® |
| CMMI | Capability Maturity Model® IntegrationSM |
| COTS | Commercial off the shelf |
| CPR | Center Procedural Requirements |
| CPU | Central Processing Unit |
| DGA | Designated Governing Authority |
| DR | Decommissioning Review |
| DRR | Disposal Readiness Review |
| ECP | Engineering Change Proposal |
| EEE | Electrical, Electronic, and Electromechanical |
| EMC | Electromagnetic Compatibility |
| EMI | Electromagnetic Interference |
| ETA | Engineering Technical Authority |
| FA | Formulation Agreement |
| FAD | Formulation Authorization Document |
| FRR | Flight Readiness Review |
| GOTS | Government off the shelf |
| HSIP | Human Systems Integration Plan |
| ICD | Interface Control Document |
| ICWG | Interface Control Working Group |
| ILSP | Integrated Logistics Support Plan |
| IMS | Integrated Master Schedule |
| IP | Institutional Projects |
| IPD | Integrated Product Development |
| IPPD | Integrated Product and Process Development |
| IT | Information Technology |
| JCL | Joint Confidence Level |
| LRR | Launch Readiness Review |
| LV | Launch Vehicle |
| KDP | Key Decision Point |
| KPP | Key Performance Parameter |
| MCR | Mission Concept Review |
| MD | Mission Directorate |
| MDAA | Mission Directorate Associate Administrator |
| MDR | Mission Definition Review |
| MOE | Measures of Effectiveness |
| MOP | Measures of Performance |
| MOTS | Modified off the shelf |
| MRR | Mission Readiness Review |
| MSO | Mission Support Office |
| MSOD | Mission Support Office Director |
| NID | NASA Interim Directive |
| NODIS | NASA On-Line Directives Information System |
| NPD | NASA Policy Directive |
| NPR | NASA Procedural Requirements |
| NTIA | National Telecommunications & Information Administration |
| OCE | Office of the Chief Engineer |
| ORR | Operational Readiness Review |
| OSMA | Office of Safety and Mission Assurance |
| PCA | Program Commitment Agreement |
| PDLM | Product Data and Life-cycle Management |
| PDR | Preliminary Design Review |
| PFAR | Post-Flight Assessment Review |
| PIR | Program Implementation Review |
| PLAR | Post-Launch Assessment Review |
| PM | Program or Project Manager |
| PMC | Program Management Committees |
| PRA | Probabilistic Risk Assessment |
| PRR | Production Readiness Review |
| PSR | Program Status Review |
| RF | Radio Frequency |
| RFA | Request for Action |
| RFP | Request for Proposal |
| RID | Review Item Discrepancy |
| SandMA | Safety and Mission Assurance |
| SAR | System Acceptance Review |
| SDR | System Definition Review |
| SE | Systems Engineering |
| SEMP | Systems Engineering Management Plan |
| SE NPR | Systems Engineering NASA Procedural Requirements |
| SIR | System Integration Review |
| SMSR | Safety and Mission Success Review |
| SP | Special Publication |
| SRB | Standing Review Board |
| SRR | System Requirements Review |
| TA | Technical Authority |
| TBD | To Be Determined |
| TBR | To Be Resolved |
| TPM | Technical Performance Measure |
| TRL | Technology Readiness Level |
| TRR | Test Readiness Review |
| USC | United States Code |
| VandV | Verification and Validation |
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