| Directive ID | Subject | Effective Period |
| NPR 1040.1A | NASA Continuity of Operations (COOP) Planning Procedural Requirements Document | June 26, 2025 to June 26, 2030 |
| NPR 1058.1 | NASA Enterprise Protection Program (w/Change 1) | June 14, 2019 to December 30, 2025 |
| NPR 1080.1B | Requirements for the Conduct of NASA Research and Technology (R&T) Revalidated w/ Change 1 for Another Five Years | February 21, 2017 to March 21, 2030 |
| NPR 1152.1 | NASA Charters and Agency Governance Council Procedural Requirements | September 23, 2024 to September 23, 2029 |
| NPR 1371.1 | Requests For Waivers Of The Residence Abroad Requirements For Exchange Visitors Sponsored By NASA Contractors And Grantees w/Change 5 | November 26, 1997 to June 11, 2029 |
| NPR 1382.1B | NASA Privacy Procedural Requirements | July 26, 2022 to July 26, 2027 |
| NPR 1385.1A | Public Appearances of NASA Personnel, Including Astronauts | March 4, 2020 to September 30, 2025 |
| NPR 1387.1A | NASA Exhibits Program | April 11, 2018 to December 31, 2025 |
| NPR 1400.1I | NASA Directives Procedural Requirements | November 1, 2024 to November 1, 2029 |
| NPR 1400.2 | Regulatory Management Procedural Requirements | November 26, 2024 to November 26, 2029 |
| NPR 1441.1E | NASA Records Management Program Requirements (Updated w/Change 3) | January 29, 2015 to May 23, 2026 |
| NPR 1450.10E | Office of the Administrator Correspondence, Actions, and Clearance Procedural Requirements | September 27, 2024 to September 27, 2029 |
| NPR 1450.4H | Congressional Correspondence, Actions and Clearance Procedural Requirements | June 23, 2025 to June 23, 2030 |
| NPR 1600.1A | NASA Security Program Procedural Requirements (Updated with Change 1) | August 12, 2013 to December 12, 2028 |
| NPR 1600.2B | NASA Classified National Security Information (CNSI) | July 25, 2025 to July 25, 2030 |
| NPR 1600.3B | Personnel Security | June 6, 2025 to June 6, 2030 |
| NPR 1600.4B | Identity and Credential Management | August 3, 2025 to August 3, 2030 |
| NPR 1600.6A | Communications Security (COMSEC) | July 12, 2021 to July 12, 2026 |
| NPR 1620.2B | Facility Security Level Determinations | June 21, 2021 to June 21, 2026 |
| NPR 1620.3B | Physical Security Requirements for NASA Facilities and Property (Administrative changes made on June 23, 2025) | May 13, 2019 to December 31, 2029 |
| NPR 1660.1C | NASA Counterintelligence and Counterterrorism | May 7, 2015 to December 7, 2030 |
| NPR 1800.1E | NASA Occupational Health Program Procedures w/Change 2 | March 16, 2023 to March 16, 2028 |
| NPR 1850.1A | Quality Assurance of NASA Medical Care | June 19, 2025 to June 19, 2030 |
| NPR 1900.3C | Ethics Program Management | December 7, 2020 to December 7, 2025 |
| NPR 2081.1B | Nondiscrimination in Federally Assisted and Conducted Programs (Updated w/Change 1) | June 23, 2021 to June 23, 2026 |
| NPR 2092.1B | Distribution of Royalties and Other Payments Received by NASA from the Licensing or Assignment of Inventions (Revalidated 7/31/19) | August 22, 2014 to December 31, 2026 |
| NPR 2190.1C | NASA Export Control Program (Revalidated w/change 1) | September 8, 2017 to September 8, 2028 |
| NPR 2200.2E | Requirements for Documentation, Approval and Dissemination of Scientific and Technical Information (Revalidated with Change 2) | December 17, 2021 to December 17, 2031 |
| NPR 2210.1E | Release of NASA Software | June 14, 2023 to June 14, 2028 |
| NPR 2570.1C | NASA Radio Frequency (RF) Spectrum Management Manual (Revalidated w/change1) | September 22, 2014 to September 22, 2026 |
| NPR 2800.2A | Information and Communication Technology Accessibility | August 5, 2020 to April 5, 2026 |
| NPR 2810.1F | Security of Information and Information Systems (Updated with Administrative edits, Change 1) | January 3, 2022 to January 3, 2027 |
| NPR 2810.2A | Possession and Use of NASA Information and Information Systems Outside of the United States | October 3, 2024 to October 3, 2029 |
| NPR 2810.7 | Controlled Unclassified Information (Updated with Change 1) | October 22, 2021 to October 22, 2026 |
| NPR 2830.1A | NASA Enterprise Architecture Procedures | December 19, 2013 to December 19, 2026 |
| NPR 2841.1 | Identity, Credential, and Access Management (Revalidated w/change 2) | January 6, 2011 to January 6, 2027 |
| NPR 3100.1C | Management of the Senior Executive Service (SES) (Updated with Change 2) | December 21, 2020 to December 21, 2026 |
| NPR 3300.1C | Employment, Appointment Authorities, and Details | November 1, 2015 to December 31, 2030 |
| NPR 3319.1C | Management of Scientific and Professional (ST) and Senior-Level (SL) Positions (Updated with Change 1) | September 2, 2021 to September 2, 2027 |
| NPR 3330.1C | NASA Career Transition Assistance Plans (CTAPs) Updated with Change 2 | September 27, 2022 to September 27, 2027 |
| NPR 3335.1J | Merit Promotion and Placement (Updated with Change 2) | June 29, 2023 to June 29, 2028 |
| NPR 3430.1D | Employee Performance and Communication System (EPCS) (Updated w/Change 3 on February 16, 2023) | October 19, 2016 to April 19, 2028 |
| NPR 3435.1D | NASA Performance Management System for the Senior Executive Service (Updated with Change 1, on August 3, 2023) | December 7, 2020 to December 7, 2026 |
| NPR 3451.1C | NASA Awards and Recognition Program, (Revalidated on July 17, 2024 w/ Change 1) | December 6, 2017 to October 31, 2029 |
| NPR 3451.3 | NASA Space Flight Awareness Program (Revalidated for another 5 years) | August 26, 2025 to August 26, 2030 |
| NPR 3530.1C | NASA Pay and Compensation Policy | January 12, 2009 to June 2, 2026 |
| NPR 3600.1C | Attendance and Leave | September 1, 2022 to September 1, 2027 |
| NPR 3600.2B | NASA Telework Program Updated w/Change 2 | September 23, 2019 to September 23, 2029 |
| NPR 3713.1C | Reasonable Accommodations Procedures for Individuals with Disabilities (Updated with Change 1) | April 22, 2019 to April 22, 2026 |
| NPR 3713.2B | Alternative Dispute Resolution in Discrimination Complaints (Updated with Change 1) | May 22, 2017 to December 1, 2025 |
| NPR 3713.3A | Anti-Harassment Procedures (Updated with Change 3) | January 12, 2021 to January 12, 2031 |
| NPR 3730.1A | NASA Suitability Program (Updated with Change 2) | June 13, 2018 to December 13, 2028 |
| NPR 3771.1A | NASA's Administrative Grievance System (AGS) Revalidated on October 25, 2024 w/Change 2 | January 21, 2016 to January 21, 2030 |
| NPR 3790.1 | NASA's Domestic Violence, Sexual Assault, and Stalking Response Plan (Updated with Change 3) | April 30, 2019 to December 11, 2029 |
| NPR 3792.1D | NASA’s Plan for a Drug Free Workplace (Revalidated w/Change 3) | May 14, 2018 to November 14, 2030 |
| NPR 3831.1 | Phased Retirement (Revalidated with Change 1) | October 11, 2016 to December 11, 2028 |
| NPR 4000.1 | NASA Logistics Management Operations Compensating Controls Reviews, (Revalidated with Change 2, March 21, 2022) | April 9, 2010 to June 9, 2027 |
| NPR 4100.1F | NASA Supply Support and Materiel Management (Revalidated with Change 2, on March 7, 2022) | March 7, 2017 to March 7, 2027 |
| NPR 4200.1H | NASA Equipment Management Procedural Requirements | March 8, 2017 to June 8, 2026 |
| NPR 4300.1C | NASA Personal Property Disposal Procedural Requirements | June 27, 2013 to December 31, 2027 |
| NPR 4310.1A | Artifact Identification and Disposition Revalidated w/Change 1 | May 12, 2014 to May 12, 2026 |
| NPR 4320.1 | Identification and Recovery of NASA Personal Property | June 23, 2021 to June 23, 2026 |
| NPR 4500.1A | Administration of Property in the Custody of Award Recipients | April 10, 2024 to April 10, 2029 |
| NPR 5200.1E | Industrial Labor Relations (Revalidated with Change 1, on September 3, 2024) | August 13, 2019 to August 13, 2029 |
| NPR 6000.1H | Requirements for Packaging, Handling, and Transportation for Aeronautical and Space Systems, Equipment, and Associated Components | November 10, 2010 to June 10, 2026 |
| NPR 6200.1D | NASA Transportation and General Traffic Management | May 1, 2014 to June 1, 2026 |
| NPR 7100.1D | Protection of Human Research Subjects | April 26, 2024 to April 26, 2029 |
| NPR 7100.5 | Curation of Astromaterials | August 16, 2023 to August 16, 2028 |
| NPR 7120.10B | Technical Standards for NASA Programs and Projects | June 1, 2022 to June 1, 2027 |
| NPR 7120.11A | NASA Health and Medical Technical Authority (HMTA) Implementation | September 8, 2020 to September 8, 2026 |
| NPR 7120.5F | NASA Space Flight Program and Project Management Requirements w/Change 4 | August 3, 2021 to August 3, 2026 |
| NPR 7120.7A | NASA Information Technology Program and Project Management Requirements (Updated with Change 2) | August 17, 2020 to August 17, 2030 |
| NPR 7120.8A | NASA Research and Technology Program and Project Management Requirements (Revalidated w/change 5) | September 14, 2018 to September 14, 2028 |
| NPR 7123.1D | NASA Systems Engineering Processes and Requirements Updated w/Change 2 | July 5, 2023 to July 5, 2028 |
| NPR 7150.2D | NASA Software Engineering Requirements | March 8, 2022 to March 8, 2027 |
| NPR 7500.2A | NASA Technology Transfer Requirements | June 16, 2022 to June 16, 2027 |
| NPR 7900.3D | Aircraft Operations Management | May 1, 2017 to February 17, 2026 |
| NPR 8000.4C | Agency Risk Management Procedural Requirements | April 19, 2022 to April 19, 2027 |
| NPR 8079.1 | NASA Spacecraft Conjunction Analysis and Collision Avoidance for Space Environment Protection | June 27, 2023 to June 27, 2028 |
| NPR 8510.1A | NASA Cultural Resources Management | June 20, 2017 to March 15, 2026 |
| NPR 8553.1C | NASA Environmental Management System | July 20, 2020 to December 30, 2025 |
| NPR 8570.1B | NASA Energy and Water Management Program | August 31, 2020 to August 28, 2026 |
| NPR 8580.1A | Implementing the National Environmental Policy Act and Executive Order 12114 (Revalidated with Change 2 on April 1, 2025) | August 1, 2012 to February 1, 2031 |
| NPR 8590.1A | Environmental Compliance and Restoration Program (Revalidated on April 5, 2016 with Change 1) | July 18, 2011 to June 30, 2026 |
| NPR 8600.1 | NASA Capability Portfolio Management Requirements | April 22, 2019 to September 30, 2025 |
| NPR 8621.1D | NASA Procedural Requirements for Mishap and Close Call Reporting, Investigating, and Recordkeeping (updated w/Change 4) | July 6, 2020 to December 30, 2025 |
| NPR 8705.2C | Human-Rating Requirements for Space Systems (Updated w/Change 2) | July 10, 2017 to December 16, 2026 |
| NPR 8705.4B | Risk Classification for NASA Payloads | November 1, 2024 to November 1, 2029 |
| NPR 8705.6D | Safety and Mission Assurance (SMA) Audits, Reviews, and Assessments | March 29, 2019 to December 31, 2026 |
| NPR 8715.1B | NASA Safety and Health Programs | February 1, 2021 to February 1, 2026 |
| NPR 8715.24 | Planetary Protection Provisions for Robotic Extraterrestrial Missions | September 24, 2021 to September 24, 2026 |
| NPR 8715.26 | Nuclear Flight Safety | February 3, 2022 to February 3, 2027 |
| NPR 8715.2B | NASA Emergency Management Program Procedural Requirements (Revalidated with Change 1) | November 19, 2014 to January 29, 2030 |
| NPR 8715.3E | Requesting Relief from Agency Mission Assurance Requirements | June 10, 2024 to June 10, 2029 |
| NPR 8715.5B | Range Flight Safety Program | February 2, 2018 to August 23, 2026 |
| NPR 8715.6E | Orbital Debris Mitigation | April 18, 2024 to April 18, 2029 |
| NPR 8715.7B | Payload Safety Program | April 27, 2020 to April 27, 2030 |
| NPR 8735.1D | Exchange of Problem Data Using NASA Advisories and the Government-Industry Data Exchange Program (GIDEP) | April 2, 2018 to October 14, 2026 |
| NPR 8735.2C | Hardware Quality Assurance Program Requirements for Programs and Projects (Updated w/Change 2) | March 12, 2021 to March 12, 2026 |
| NPR 8800.15F | Real Estate Management Program (Updated with Change 2) | October 8, 2024 to October 8, 2029 |
| NPR 8810.1A | Center Master Planning | February 13, 2013 to December 31, 2025 |
| NPR 8820.2I | Facility Project Requirements (FPR) (Updated with Administrative edits w/Change 1) | September 4, 2024 to September 4, 2029 |
| NPR 8831.2F | Facilities Maintenance and Operations Management (Updated w/Change 1 on September 2, 2016) | October 7, 2015 to May 6, 2026 |
| NPR 8900.1B | NASA Health and Medical Requirements for Human Space Exploration | December 16, 2016 to March 8, 2026 |
| NPR 8910.1D | Care and Use of Animals | February 9, 2022 to February 9, 2027 |
| NPR 9010.1A | Financial Management Requirements Overview | May 31, 2018 to December 30, 2025 |
| NPR 9010.2B | The Continuous Monitoring Program of Financial Controls | May 31, 2018 to June 30, 2026 |
| NPR 9010.3A | Financial Management Internal Control | February 3, 2020 to June 30, 2026 |
| NPR 9050.1A | Official Representational Fund (Revalidated 12/11/2020) | November 4, 2002 to November 4, 2025 |
| NPR 9050.2B | Advances and Prepayments | March 29, 2019 to December 31, 2025 |
| NPR 9050.3A | The Antideficiency Act - Compliance, Violations, and Investigations | September 6, 2024 to September 6, 2029 |
| NPR 9060.1B | Accrual Accounting - Revenues, Expenses, and Program Costs | April 24, 2023 to April 24, 2028 |
| NPR 9090.1C | Partnership Agreements – Financial Requirements and Administration (Updated with Change 2) | February 23, 2023 to February 23, 2028 |
| NPR 9095.1 | Working Capital Fund Policies and Requirements (Revalidated with Change 1, on January 24, 2018) | September 30, 2008 to October 14, 2025 |
| NPR 9130.1A | NASA Financial Information Systems | July 8, 2021 to July 8, 2026 |
| NPR 9200.1 | Accounting General Overview (Revalidated 7/31/2018 with Change 2) | September 30, 2008 to May 31, 2026 |
| NPR 9210.1A | Fund Balance with Treasury (Revalidated on January 31, 2019 w/Change 1) | July 3, 2014 to July 7, 2026 |
| NPR 9220.1B | Journal Voucher Preparation and Approval and Intragovernmental Transactions Change 2, (Revalidated September 24, 2020) | February 9, 2017 to February 9, 2026 |
| NPR 9250.1C | Property, Plant, and Equipment and Operating Materials and Supplies | October 29, 2015 to May 23, 2026 |
| NPR 9260.1A | Liabilities (Revalidated with Change 2 April 19, 2023) | February 9, 2015 to February 9, 2029 |
| NPR 9290.1A | Special Accounts (Revalidated on March 6, 2024) | April 11, 2011 to August 26, 2028 |
| NPR 9310.1A | Financial Management Reports - Accounting, (Updated w/Change 2 February 21, 2018) | March 15, 2013 to March 15, 2026 |
| NPR 9330.1 | External Reports-Budget | August 1, 2017 to March 15, 2026 |
| NPR 9420.1A | Budget Formulation (Revalidated on September 15, 2021 with Change 1) | September 7, 2016 to September 7, 2026 |
| NPR 9470.1A | Budget Execution | August 30, 2024 to August 30, 2029 |
| NPR 9501.2E | NASA Contractor Financial Management Reporting (Updated w/Change 4) | May 27, 2011 to November 27, 2028 |
| NPR 9610.1B | Accounts Receivable and Debt Administration | August 8, 2022 to August 8, 2027 |
| NPR 9620.1A | Payroll (Updated w/Change 1 on August 29, 2023) | May 17, 2017 to May 17, 2027 |
| NPR 9630.1A | Accounts Payable and Disbursements | February 1, 2024 to February 1, 2029 |
| NPR 9640.1A | Financial Management of Contractor Claims Against NASA (Revalidated with Change 1, October 3, 2024) | October 28, 2019 to October 28, 2029 |
| NPR 9690.1 | Investments (Revalidated, December 11, 2017) | September 30, 2008 to December 31, 2026 |
| NPR 9710.1 | General Travel Requirements (Updated with Change 2 June 28, 2021) | June 20, 2018 to December 31, 2026 |
| NPR 9730.1 | Travel Cards (Revalidated on March 21, 2024) | March 29, 2019 to March 24, 2029 |
| NPR 9750.1 | Extended Temporary Duty Travel (ETDY) | May 9, 2018 to June 9, 2028 |
| NPR 9760.1 | Relocation Allowances (Revalidated with Change 1 on April 24, 2023) | February 13, 2018 to June 21, 2028 |
| NPR 9770.1A | NASA Conference Approval and Reporting | November 17, 2020 to December 31, 2026 |
| NPR 9780.1 | Payment of Expenses Connected With the Death of Certain Employees, Revalidated on January 24, 2023 with Change 1. | January 17, 2017 to July 17, 2028 |
| NPR 9790.1 | Payment of Travel Expense from a Non-Federal Source, Revalidated on August 30, 2022 | August 30, 2017 to August 30, 2027 |